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With an unpaired electron, NO, which is a highly reactive free radical, damages proteins, carbohydrates, nucleotides and lipids and, together with other inflammatory mediators, results in cell and tissue damage, low-grade, sterile inflammation and adhesions [20]

However, in randomized controlled trials, consuming excess folic acid (the form of folate in supplements and fortified foods) from supplements has increased risk of some cancers

95% confidence intervals [CI], 1.66 to 0.09)

This reaction can generate more toxic radicals through interactions between the superoxide (SO) anion and hydrogen peroxide (H 2 O 2 ) [12, 13]

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Dryness and loss of natural hydration